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TRENDING OPEN SCIENCE
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Structural basis for Fc receptor recognition of immunoglobulin M
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By
Qu Chen
Rajesh Menon
Pavel Tolar
Peter B. Rosenthal
DOI: 10.1101/2022.11.18.517032
On bioRxiv: https://biorxiv.org/content/10.1101/2022.11.18.517032v1
FcR is the IgM-specific Fc receptor involved in the survival and
activation of B cells. Using cryo-EM, we reveal eight binding sites
for the human FcR Ig domain on the IgM pentamer, one of which overlaps
a different mode of binding explains Ig isotype specificity. The
complex explains engagement with polymeric serum IgM and the monomeric
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RANKS:
- Overall rank: 163746
- Rank in molecular-biology: 4957
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