[CONTACT]

[ABOUT]

[POLICY]

TRENDING OPEN SCIENCE Tracing the o

Found at: origin.rxivist.org:70/papers/212659

               _____          _         _       _
              |  __ \        (_)       (_)     | |
              | |__) |__   __ _ __   __ _  ___ | |_
              |  _  / \ \ / /| |\ \ / /| |/ __|| __|
              | | \ \  \ v / | | \ V / | |\__ \| |_
              |_|  \_\  > <  |_|  \_/  |_||___/ \__|
                       / ^ \
                      /_/ \_\
                      TRENDING OPEN SCIENCE
-------------
Tracing the origin of pathologic pulmonary fibroblasts
--------
By
  Tatsuya Tsukui
  Dean Sheppard
DOI: 10.1101/2022.11.18.517147
On bioRxiv: https://biorxiv.org/content/10.1101/2022.11.18.517147v1
Fibroblasts substantially remodel extracellular matrix (ECM) in
mportance of injury-induced fibroblast lineages remain unclear. Here
maintaining alveolar type 2 cells in uninjured lungs, are the dominant
to facilitate fibrosis after lung injury. We demonstrate that Cthrc1+
fibroblasts, which express the highest levels of ECM proteins at
njured sites, are effector cells for fibrogenesis using a novel mouse
tool, Cthrc1-CreER. We use another novel mouse tool, Scube2-CreER,
that uniquely targets alveolar fibroblasts, to reveal that alveolar
fibroblasts are the dominant origin for multiple fibroblast subsets
that emerge after lung injury. Pseudotime and in vitro analysis
can differentiate into Cthrc1+ fibrotic fibroblasts in response to
TGF-b. We identify similar fibroblast lineages from scRNA-seq in human
lineage development in response to lung injury and suggest that
targeting key steps in transitions among these subsets could provide
novel strategies for the treatment of fibrotic diseases.
---
RANKS:
  - Overall rank: 127482
  - Rank in pathology: 781
______________________________________________________________________
                                          Served by Flask-Gopher/2.0.0


AD: