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TRENDING OPEN SCIENCE
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Endonuclease fingerprint indicates a synthetic origin of SARS-CoV-2
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By
Valentin Bruttel
Alex Washburne
Antonius VanDongen
DOI: 10.1101/2022.10.18.512756
On bioRxiv: https://biorxiv.org/content/10.1101/2022.10.18.512756v1
To prevent future pandemics, it is important that we understand
ndirectly in a laboratory accident. The genome of SARS-COV-2 contains
a peculiar pattern of unique restriction endonuclease recognition
characteristic of synthetic viruses. Here, we report the likelihood of
observing such a pattern in coronaviruses with no history of
bioengineering. We find that SARS-CoV-2 is an anomaly, more likely a
these synthetic-looking recognitions sites, and has a synthetic
fingerprint unlikely to have evolved from its close relatives. We
nfectious clone assembled in vitro.
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RANKS:
- Overall rank: 112
- Rank in bioengineering: 1
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