[CONTACT]

[ABOUT]

[POLICY]

TRENDING OPEN SCIENCE single amino

Found at: origin.rxivist.org:70/papers/207330

               _____          _         _       _
              |  __ \        (_)       (_)     | |
              | |__) |__   __ _ __   __ _  ___ | |_
              |  _  / \ \ / /| |\ \ / /| |/ __|| __|
              | | \ \  \ v / | | \ V / | |\__ \| |_
              |_|  \_\  > <  |_|  \_/  |_||___/ \__|
                       / ^ \
                      /_/ \_\
                      TRENDING OPEN SCIENCE
-------------
A single amino acid change drives left- right asymmetry in Bilateria
--------
By
  Marta Truchado-Garcia
  Kimberly J. Perry
  Florencia Cavodeassi
  Nathan J. Kenny
  Jonathan Q Henry
  Cristina Grande
DOI: 10.1101/2022.10.06.511172
On bioRxiv: https://biorxiv.org/content/10.1101/2022.10.06.511172v1
Asymmetries are essential for proper organization and function of
organ systems. Genetic studies in deuterostomes have shown signaling
through the Nodal/Smad2 pathway plays a key, conserved role in the
establishment of body asymmetries. While Nodal signaling is required
for the establishment of left-right asymmetry (LRA) across bilaterian
master regulator of the Nodal pathway in vertebrates, in several
nvertebrate species, the first evidence of its presence in non-
amino acid mutation in the egf-cfc gene in the deuterostome common
ancestor was the necessary step in inducing a gain-of-function in LRA
appeared in the bilaterian stem lineage, before being adopted as a
master mechanism to regulate the Nodal pathway and the establishment
of LRA in deuterostomes.
---
RANKS:
  - Overall rank: 144250
  - Rank in developmental-biology: 3852
______________________________________________________________________
                                          Served by Flask-Gopher/2.0.0


AD: